I have always wanted to investigate
Murine , primate , cell line and human blood tumors!
Larry H. Bernstein, MD, FCAP, Curator
Tumor Models Bridge Mouse-Human Gap
Revamped Allograft and Innovative Xenograft Models Can Reduce the Risks of Late-Stage Clinical Trials and Increase the Odds of Translational Success
CRISPR-Cas9 sgRNA in vitro screens can be used to look for genes that when lost induce resistance to a drug (positive screen) or increase sensitivity to a drug (negative screen). The technology might also be a powerful tool for target ID screens in vivo, and looks set to aid in our understanding of tumor development and progression in animal models. [Horizon Discovery]
Precision medicine is all about the two T’s—targets and treatments—targets that emerge from analyses of patient-specific information, and treatments that hit these targets. Both T’s, however, pose difficulties. All too often, insights and drug candidates originating in precision medicine fail to translate into clinical practice.
This reality prompted sober comments…
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