Cancer Driver Mutations
Larry H. Bernstein, MD, FCAP, LPBI
Big Data Screen Uncovers New Cancer Driver Genes
Using publicly available information from genomic and proteomic databases, a team of scientists lead by researchers at Sanford Burnham Prebys Medical Discovery Institute (SBP) have created a new and more comprehensive catalog of driver mutations for cancer. Driver mutations are genes that handle the progression of cancerous growths. The researchers used cancer mutation and protein structure databases to identify mutations in patient tumors that alter normal protein-protein interaction (PPI) interfaces—identifying more than 100 novel cancer driver genes that may help explain how tumors that are driven by the same gene often lead to vastly different clinical outcomes.
“This is the first time that three-dimensional protein features, such as PPIs, have been used to identify driver genes across large cancer datasets,” explained lead author Eduard Porta-Pardo, Ph.D., postdoctoral fellow at SBP. “We…
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